Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (29): 5445-5449.doi: 10.3969/j.issn. 2095-4344.2012.29. 026

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Application and progress of heparin-coated technology in biomedical materials

Gao Wen-qing1, Li Tong2, Yu Mei-li3   

  1. 1Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China;
    2Department of Heart Center, Tianjin Third Central Hospital, Tianjin 300170, China;
    3Key Laboratory of Artificial Cells of Tianjin, Tianjin 300170, China
  • Received:2011-12-29 Revised:2012-01-10 Online:2012-07-15 Published:2012-07-15
  • Contact: Li Tong, Doctor, Chief physician, Department of Heart Center, Tianjin Third Central Hospital, Tianjin 300170, China litongtj@163.om
  • About author:Gao Wen-qing★, Master, Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China qw_1224@ hotmail.com

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Abstract:

BACKGROUND: For the past few years, the application of heparin coating technology is an active field in biomedical materials. Coating methods, coating models and coating materials are in great development.
OBJECTIVE: To summarize the investigative situation and progression about different coating models in accordance with different methods and protection of heparin active groups.
METHODS: A computer-based research was performed in CNKI database, PubMed database and US patent database to search the related articles about the application of heparin coating technology in biomedical materials. The key words were “heparin, coating technology, bond method, medical materials, anticoagulation activity” in Chinese and English. The articles related to the heparin coating technology were selected, and articles in the same field that published recently or in authorized journals were preferred. There were 161 articles after the initial survey. Then 29 articles related to heparin coating technology were involved according to the inclusion criteria.
RESULTS AND CONCLUSION: Heparin coating technology can simulate the anticoagulant mechanism of vascular endothelial cells, and improve the biocompatibility and anticoagulation activity through modification of biomedical materials surface. Heparin coating technology will make great development and application by increasing the stability and quantity of bonded heparin and retaining heparin activity on biomaterial surface.

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